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The City of Cottleville in St. Charles County was named the safest city in Missouri by for the second consecutive year.

The City of O'Fallon also made the top 10 and was again the only city with a population of more than 75,000 to be recognized.

St. Louis Arch

U-Haul® ranks the St. Louis region among the top growth areas in the US for 2022.

The ranking is based on the net gain of one-way U-Haul® trucks during the past year.

St. Charles Riverfront

Construction Begins on St. Charles' Riverpointe

CRG and Clayco have started construction on the first phases of Riverpointe, a $350 million development more than a decade in the making, which, over the next five years, looks to revitalize 120 acres along the Missouri River at Interstate 70 and Main Street, building on the success of the neighboring 27-acre mixed-use development that opened in 2012, The Streets of St. Charles.

St. Peters MO

St. Peters Named #22 Best Place To Live

Money Magazine has named the City of St. Peters to its 2021 list of the Best Places to Live in America. St. Peters was the only Missouri city named to the 2021 list.

St. Charles County Among Healthiest in Missouri

For the 13th consecutive year, St. Charles County is recognized by the Robert Wood Johnson Foundation and the University of Wisconsin’s Population Health Institute among the state’s healthiest.

The rankings place St. Charles County among Missouri and the nation’s top performers in many of the evaluated sections.

Katy Trail

Katy Trail State Park has been named the #2 Recreational Trail in the nation in USA Today’s 10 Best Readers’ Choice Awards

Did you know the trailhead for the Katy Trail is in St. Charles County? The portion running through St. Charles County is also some of the most used portion of the trail.  Read more about this year's rankings.

Best Place To Start A Business

St. Charles County Among The Best Places To Start A Business

WalletHub recently released it list of best and worst places to start a business and four St. Charles County (Wentzville, St. Charles, St. Peters, and O'Fallon) rank among the Top 500 of best places to start a business!  More than 1,300 cites were evaluated on their business-friendliness.

Welcome to the St. Charles Regional Chamber

Welcome to the home page of the St. Charles Regional Chamber! We're glad you're here!

Our Mission: We advocate for our business community by developing opportunities and partnerships that strengthen the economic prosperity and sustainability of our region.

Mark Your Calendar

La Belle Vie - 2023 Small Business of the Year

The St. Charles Regional Chamber is pleased to recognize La Belle Vie /  The Cafe at Frenchtown as its 2023 Small Business of the Year!!  Congratulations to owners Mark and Melissa Hollander.

2023 Finalists:

Budget Heating, Cooling, & Plumbing

Ninni Co.


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Learn More

Multi-Chamber Business After Hours - June 28

Join us at Centene Community Ice Center / St. Louis Music Park for a regional networking event hosted by chambers of commerce in the western region of St. Louis. Food & drinks available.

Learn More & Register To Attend

Shop Where I Live

The St. Charles Regional Chamber has brought a whole new way to shop local through a new online marketplace.

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Sign Up To Become A Seller

NOW SELLING: The ShopSt.C Digital Gift Card 

We are pleased to announce the new ShopSt.C Digital Gift Card, an e-card that makes it fun and easy to keep local spending local.

Sponsored by Mastercard

We are currently signing up local businesses to participate in the program.

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Purchase a Card or Sign Up Your Business (scroll to bottom)

Community Resource Guide

The Chamber's Community Resource Guide provides information on St. Charles County and is great for anyone looking to relocate or open a business here. Click on the link below to view online or call 636.946.0633 to have one mailed.

Community Resource Guide

Chamber Benefit Plan

The Chamber Benefit Plan is a self-funded medical offering built on the multiple employer welfare arrangement model. This program enables smaller employers to join together to share in the overall claims risk.

Powered by the Missouri Chamber Federation and administered by Anthem Blue Cross and Blue Shield, the Chamber Benefit Plan is available to small group employers in Missouri who have 2 to 50 eligible employees.

Elite Members